Scene iii:
At his castle, Macbeth tells the Doctor that he does not fear the invasion force because of the predictions of the witches that no man born of woman can kill him and that the woods must march before he is defeated. The Doctor tells Macbeth that his wife is afflicted by insomnia and hallucinations.

Scene iv:
Near Birnam Wood, Malcolm, Macduff and their force assemble for the assault upon Macbeth's castle, Malcolm instructing his men to camouflage themselves with branches from the trees of Birnam Wood.

Scene v:
At his castle, Macbeth is told that his wife, Lady Macbeth, is dead. Macbeth is stunned, saying that life "is a tale/Told by an idiot, full of sound and fury/Signifying nothing." Just then, a messenger arrives with the word that Birnam Wood is "marching" on Dunsinane. Macbeth realizes what this means in terms of the prophecies, but vows to fight on, still assured that no man born of woman can kill him.

Scene vi:
Malcolm, Macduff and a lord of their party, Siward, prepare to assault the walls of Macbeth's castle.

Scene vii:
Macbeth appears in armor and kills Siward. He encounters Macduff and the two duel throughout the remainder of the scene.

Scene viii:
As the fight between them continues, Macduff tells Macbeth that he is not a "natural" product of his mother's womb, that he was prematurely ripped from it and (technically) is "not of woman born." Macbeth faces the challenge bravely, telling his foe to "Lay on, Macduff." Macduff does just that and kills Macbeth. Macduff appears carrying Macbeth's severed head and hails Malcolm as the new king of Scotland. Malcolm says that when he is crowned, he will make Macduff and his supporters Earls of the realm as they all celebrate the triumph over Macbeth, Lady Macbeth and the evil that they wrought in Scotland.